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人组织激肽释放酶4在子宫内膜癌中的表达和预后的关系
  • 摘要

    目的:探讨人组织激肽释放酶4( KLK4)在子宫内膜癌中的表达和对预后的影响,为改善子宫内膜癌的预后提供新的思路。方法免疫组化法检测81例子宫内膜癌、30例不典型增生的子宫内膜和30例正常子宫内膜中KLK4的表达情况,收集患者临床病理资料,结合随访资料做生存分析,并分析KLK4的表达和子宫内膜癌预后的关系。结果 KLK4在正常内膜、不典型增生内膜和子宫内膜癌中的高表达率分别为30%、53%、67%,差异有统计学意义(χ2=12.059,P=0.002);KLK4的高表达和子宫内膜癌的分化程度及深肌层浸润相关(χ2=7.985,P=0.021;χ2=4.629,P=0.031),与年龄、临床分期、淋巴结转移无关(χ2值分别为0.266、1.761、0.277,均P>0.05);KLK4高表达组的5年无进展生存率较低表达组更低,差异有统计学意义(P=0.032)。结论 KLK4的高表达可能与子宫内膜癌细胞的分化和局部侵袭有关,其高表达提示早期复发,KLK4有可能作为预测子宫内膜癌早期复发的标志物。

  • 作者

    张千峰  李佳  刘海霞  邸曼  周卓  陈必良  ZHANG Qian-feng  LI Jia  LIU Hai-xia  DI Man  ZHOU Zhuo  CHEN Bi-liang 

  • 作者单位

    第四军医大学西京医院妇产科,陕西西安,710032

  • 刊期

    2014年6期 ISTIC

  • 关键词

    组织激肽释放酶4  子宫内膜癌  免疫组化  预后  生存分析  kallikrein 4 (KLK4)  endometrial carcinoma  immunohistochemistry  prognosis  survival analysis 

参考文献
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